PhD (Fall-2017)

Teaching Philosophy: In this course I aim at to develop critical and creative thinking skills in students that will facilitate them to learn.

Learning Objectives: The students will be able to understand;

1.      Introduction to origin of life

2.      What is cell

3.      Significance of cell to life

4.      Uniqueness of cell

5.      Types of cell

6.      Components of cells (Organelles especially nucleus)

7.      Cellular Machinery

8.      Relating cells to DNA

9.      What is DNA

10.  DNA and Diversity within cell

 11.  DNA and diversity of life

12.  Genes and Genomes

13.  Mutations and Diversity

14.  Structure and function of DNA and how genome evolve.

Learning Outcomes: The students learned;

1.      How life evolved on the planet

2.      Cell is a single independently replicating and evolving entity

3.      Cell is the building block of life (if cell then life, no cell no life)

4.      Parts of cell, its property of independent replication

5.      Two types of cells i.e. eukaryotes and prokaryotes

6.      Cellular organelles (ribosomes, mitochondria etc.)

7.      Nucleus the central component necessary for replication

8.      Transcription, translation and replication

9.      Cell has nucleus that has DNA and this molecule of DNA has all the information

10.  DNA is the hereditary material, that makes genes

11.  This DNA contributes to the diversity by changing DNA sequences within a cell

12.  The same DNA molecule contributes to diversity of life

13.  Random changes in DNA sequence generate changes that generate mutations that are responsible for variety of life

Syllabus Outline:

Cells and Genomes: The Universal Features of Cells on Earth; The Diversity of Genomes and the Tree of Life Genetic Information in Eucaryotes.

DNA and Chromosomes: The structure and function of DNA; Chromosomal DNA and its packaging in the chromatin fiber; the regulation of chromatin structure; the global structure of a  chromosome; how genome evolve.

Required resources:

1. Textbook: Alberts, et al., Molecular Biology of the Cell, sixth edition. You should complete the reading assignment before class so that you are familiar with the lecture material.

_{BOOKS RECOMMENDED}

1.      Brooker, R. J. 2005. Genetics: Analysis and Principles. 2^nd edition, McGraw-Hill Book Co. Bostan, U.S.A.

2.      Costa, L. G. and Eaton, D. L. 2006. Gene-Environment Interactions; Fundamentals of Ecogenetics, John Wiley and Sons, N.Y.

3.      Dunlap, J. C. and Wu, C-Ting. 2002. Advances in Genetics: Homology Effects, Academic Press Inc., U.S.A.

4.      Gardner, E. J., Simmons, J. and Snustad, D. P. 2004. Principles of Genetics, 3^rd edition, John Wiley and Sons, N.Y.

5.      Griffiths, A. J. F., Wessler, S. R., Lewontin, R. C., Gelbart, W. M., Suzuki, D. T. and Miller, J. H. 2005. Introduction to Genetic Analysis, W.H. Freeman and Company, U.S.A.

6.      Hartl, D. L. and Jones, E. W. 2000. Genetic Analysis of Gene and Genomes, Jones and Bartlett Publishers, Sudbury, U.S.A.

7.      Hartl, D. L. and Jones, E. W. 2002. Essentials of Genetics, 3^rd edition. Jones and Bartlett Publishers, Sudbury, U.S.A.

8.      Hedrick, P.W. 2005. Genetics of Population, Jones and Bartlett Publisher, Sudbury, U.S.A.

9.      Klug, W. S. and Cummings, M. R. 2004. Concepts of Genetics, Prentice Hall, N.J.

10.  Kornberg, A. and Baker, T. A. 2005. DNA Replication, 2^nd edition, University Science Books, Sausalito, C.A.

11.  Leland, H., Leroy, H., Michael, G. L., Silver, L., Lee M., Veres, R. C. and Ann. R. 2004. Genetics, McGraw-Hill Science, N.Y.

12.  Primrose, S. B. and Twyman, R. M. 2006. Principles of Gene Manipulation and Genomics, Blackwell Scientific Publications, U.S.A.

13.  Ringo, J. 2004. Fundamental Genetics, Cambridge University Press, N.Y.

14.  Snustad, D. P. and Simmons, M. J. 2006. Principles of Genetics, 4^th edition, John Wiley and Sons, N.Y.

15.  Synder, L. and Champness, W. 2004. Molecular Genetics of Bacteria, American Society for Microbiology, Washington, D.C.

16.  Tamarin, R. H. 2002. Principles of Genetics, McGraw-Hill Science, U.S.A.

17.  Trun, N. and Trempy, J. 2004. Fundamental Bacterial Genetics, Blackwell Publishing House, U.S.A.

18.  Uldis, N., Streips, U. N., Ronald, E. and Yasbin, R. E., 2002. Modern Microbial Genetics, John Wiley and Sons, N.Y.

19.  Wilson, J and Hunt ,T.,2008. Molecular Biology of the The Cell .5^th Edition. Garland Science. Taylor and Francis Group, LLC. USA

Course Assignments and Assessments: Exams, quizzes, problem solving assignments, group work and short writing assignments will provide the opportunity to enhance your understanding and skills.